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Article

Impact of genetic variations in the WRN gene on age related pathologies and mortality.

Mechanisms of ageing and development - 1 Mar 2006

Kuningas Maris, Slagboom P Eline, Westendorp Rudi G J, van Heemst Diana

Abstract excerpt

Mutations in the WRN gene lead to the Werner syndrome (WS), which resembles premature aging. Here, we hypothesize that genetic variations in the WRN gene may also influence aging-trajectories in the population at large. To test this hypothesis, we assessed the impact of the i1-C/T, L1074F and C1367R polymorphisms in the WRN gene on the occurrence of cardiovascular pathologies, on cognitive performance and on the...

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Source

Identifiers

PMID: 16405962
DOI: 10.1016/j.mad.2005.11.005

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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