Article
Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jul 2005
Smith M A C, Silva M D A, Araujo L Q, Ramos L R, Labio R W, Burbano R R, Peres C A, Andreoli S B, Payão S L M, Cendoroglo M S
Abstract excerpt
Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.