Negative feedback defining a circadian clock: autoregulation of the clock gene frequency.

doi:10.1126/science.8128244

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Article

Negative feedback defining a circadian clock: autoregulation of the clock gene frequency.

Science (New York, N.Y.) - 18 Mar 1994

Aronson B D, Johnson K A, Loros J J, Dunlap J C

Abstract excerpt

The frequency (frq) locus of Neurospora crassa was originally identified in searches for loci encoding components of the circadian clock. The frq gene is now shown to encode a central component in a molecular feedback loop in which the product of frq negatively regulated its own transcript, which...

Topics

Base Sequence
Biological Clocks
Circadian Rhythm
Darkness
Feedback
Fungal Proteins
Gene Expression Regulation, Fungal
Gene Frequency
Genes, Fungal
Homeostasis
Light
Models, Biological
Molecular Sequence Data
Mutation
Neurospora crassa
Open Reading Frames
Quinic Acid
RNA, Fungal

Source

Open in PubMed

Identifiers

PMID: 8128244
DOI: 10.1126/science.8128244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8128244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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