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Article

FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.

Genetics - 1 Feb 2010

Shi Mi, Collett Michael, Loros Jennifer J, Dunlap Jay C

Abstract excerpt

The Neurospora circadian oscillator comprises FREQUENCY (FRQ) and its transcription activator, the White Collar Complex (WCC). Repression of WCC's transcriptional activity by FRQ via negative feedback is indispensable for clock function. An unbiased genetic screen that targeted mutants with defects in negative feedback regulation yielded a fully viable arrhythmic strain bearing a novel allele of FRQ-interacting...

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Share to Circadian Rhythm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 19948888
DOI: 10.1534/genetics.109.111393
PMCID: PMC2828717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.PMID 19948888Read ↗

Domains required for the interaction of the central negative element FRQ with its transcriptional activator WCC within the core circadian clock of Neurospora.Semantic proximity Read ↗

Functional significance of FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ.Semantic proximity Read ↗

Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH.Semantic proximity Read ↗

Temperature-sensitive and circadian oscillators of Neurospora crassa share components.Semantic proximity Read ↗

CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.Semantic proximity Read ↗

Interconnected feedback loops in the Neurospora circadian system.Semantic proximity Read ↗

Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered neurospora clock protein FRQ.Semantic proximity Read ↗

Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.Semantic proximity Read ↗

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function.Semantic proximity Read ↗

Negative feedback defining a circadian clock: autoregulation of the clock gene frequency.Semantic proximity Read ↗

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