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Article

Altered entrainment and feedback loop function effected by a mutant period protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2000

Schotland P, Hunter-Ensor M, Lawrence T, Sehgal A

Abstract excerpt

The period (per) and timeless (tim) genes encode interacting components of the circadian clock. Levels and phosphorylation states of both proteins cycle with a circadian rhythm, and the proteins drive cyclic expression of their RNAs through a feedback mechanism that is, at least in part, negative. We report here that a hypophosphorylated mutant PER protein, produced by creating a small internal deletion, displays...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10648700
PMCID: PMC6774160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered entrainment and feedback loop function effected by a mutant period protein.PMID 10648700Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

timrit Lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization.Semantic proximity Read ↗

Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.Semantic proximity Read ↗

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