Article
Altered entrainment and feedback loop function effected by a mutant period protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2000
Schotland P, Hunter-Ensor M, Lawrence T, Sehgal A
Abstract excerpt
The period (per) and timeless (tim) genes encode interacting components of the circadian clock. Levels and phosphorylation states of both proteins cycle with a circadian rhythm, and the proteins drive cyclic expression of their RNAs through a feedback mechanism that is, at least in part, negative...
Topics
- Adaptation, Physiological
- Animals
- Animals, Genetically Modified
- Behavior, Animal
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Feedback
- Gene Expression Regulation
- Insect Proteins
- Light
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Periodicity
- Phosphorylation
- RNA, Messenger
- Temperature