Mutations in the mitochondrial DNA D-Loop region occur frequently in human osteosarcoma.

Abstract excerpt

To explore the polymorphisms and mutations of mitochondrial D-Loop region in osteosarcoma and their possible association with carcinogenesis, direct DNA sequencing method was used to detect the variants of the mitochondrial D-Loop in 20 patients with osteosarcoma. We found mutations of the mitochondrial D-Loop in 14/20 (70%) of the tested osteosarcoma samples, including 34 novel mutations. We did not detect any...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Neoplasms
• Share to DNA, Mitochondrial
• Share to DNA Mutational Analysis