Article
[Screening of the gene mutation in D-loop region of mitochondrial DNA in oral squamous cell carcinoma].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology - 1 May 2013
Sun Yang, Yuan Rong-tao, Chen Wan-tao, Bu Ling-xue, Jia Mu-yun
Abstract excerpt
OBJECTIVE: To investigate the gene mutation in D-loop region of mitochondrial DNA (mtDNA) in oral squamous cell carcinoma (OSCC) tissue and to explore the role of the gene mutation in D-loop region in the OSCC tumorigenesis. METHODS: mtDNA was obtained from cancer, paracancerous and normal mucosa tissues of thirty patients with OSCC. The D-loop regions of mtDNA were amplified with PCR, sequencing and then...
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