Article
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Nature communications - 27 Jan 2015
Chandler Ronald L, Damrauer Jeffrey S, Raab Jesse R, Schisler Jonathan C, Wilkerson Matthew D, Didion John P, Starmer Joshua, Serber Daniel, Yee Della, Xiong Jessie, Darr David B, Pardo-Manuel de Villena Fernando, Kim William Y, Magnuson Terry
Abstract excerpt
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tumour formation, but requires concurrent activation of the phosphoinositide 3-kinase catalytic subunit, PIK3CA. Remarkably, the mice develop highly penetrant tumours with OCCC-like histopathology,...
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