Article
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.
PLoS genetics - 1 Dec 2021
Reske Jake J, Wilson Mike R, Holladay Jeanne, Siwicki Rebecca A, Skalski Hilary, Harkins Shannon, Adams Marie, Risinger John I, Hostetter Galen, Lin Ken, Chandler Ronald L
Abstract excerpt
TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometrium has not been elucidated. We used genetically engineered mice and in vivo genomic approaches to discern both unique and overlapping roles of TP53 and ARID1A in the...
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