Article
Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
Cancer research - 15 Oct 2021
Zundell Joseph A, Fukumoto Takeshi, Lin Jianhuang, Fatkhudinov Nail, Nacarelli Timothy, Kossenkov Andrew V, Liu Qin, Cassel Joel, Hu Chih-Chi Andrew, Wu Shuai, Zhang Rugang
Abstract excerpt
The SWI/SNF chromatin-remodeling complex is frequently altered in human cancers. For example, the SWI/SNF component ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Here, we report that ARID1A transcriptionally represses the IRE1α-XBP1 axis of the endoplasmic reticulum (ER) stress response, which confers sensitivity to inhibition of the...
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