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Article

Arid1a inactivation in an Apc‐ and Pten‐defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival

17 Aug 2015

Abstract excerpt

Inactivation of the ARID1A tumour suppressor gene is frequent in ovarian endometrioid (OEC) and clear cell (OCCC) carcinomas, often in conjunction with mutations activating the PI3K-AKT and/or canonical Wnt signalling pathways. Prior work has shown that conditional bi-allelic inactivation of the Apc and Pten tumour suppressor genes in the mouse ovarian surface epithelium (OSE) promotes outgrowth of tumours that...

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PMID: 26279473
DOI: 10.1002/path.4599

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Arid1a inactivation in an Apc‐ and Pten‐defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survivalPMID 26279473Read ↗

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