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Article

Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.

Archives of biochemistry and biophysics - 1 Mar 2015

Cho Sun-Ah, Rohn-Glowacki Katie Jo, Jarrar Yazun B, Yi Myeongjin, Kim Woo-Young, Shin Jae-Gook, Lee Su-Jun

Abstract excerpt

Prostacyclin synthase (CYP8A1) is an enzyme responsible for the biosynthesis of prostacyclin (PGI2) which inhibits platelet activation and exhibits anti-inflammatory effect. The objectives of this study were to identify CYP8A1 genetic variants and characterize functional consequences of CYP8A1 variants. In total, 27 variants including four previously unidentified single-nucleotide polymorphisms (SNPs) were...

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PMID: 25623425
DOI: 10.1016/j.abb.2015.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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