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Article

Prostacyclin synthase gene: genetic polymorphisms and prevention of some cardiovascular diseases.

Current medicinal chemistry. Cardiovascular and hematological agents - 1 Apr 2005

Nakayama Tomohiro

Abstract excerpt

Prostacyclin (PGI2) inhibits platelet aggregation and vasoconstriction. Prostacyclin synthase (PGIS), a catalyst of PGI2 synthesis from prostaglandin H2, is widely distributed and predominantly found in vascular endothelial and smooth muscle cells. The PGIS gene is localized to 20q13.11-13, and a candidate gene for cardiovascular disease. We discovered mutations and polymorphisms in this gene and reported that...

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Source

Identifiers

PMID: 15853702
DOI: 10.2174/1568016053544327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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