Article
Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacylcin synthase gene (CYP8A1).
Human genetics - 1 Feb 2001
Chevalier D, Cauffiez C, Bernard C, Lo-Guidice J M, Allorge D, Fazio F, Ferrari N, Libersa C, Lhermitte M, D'Halluin J C, Broly F
Abstract excerpt
Inheritable interindividual differences in prostacyclin production may be implicated in the pathogenesis of several human vascular diseases. Using a polymerase chain reaction/single-strand conformation polymorphism strategy, we screened for mutations in the gene encoding cytochrome P450 prostacyclin synthase (CYP8A1). DNA samples from healthy French volunteers (n = 130) of Caucasian origin were examined. Five...
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