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Article

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

Pharmacogenetics and genomics - 1 Feb 2007

Lee Craig R, Bottone Frank G, Krahn Joseph M, Li Leping, Mohrenweiser Harvey W, Cook Molly E, Petrovich Robert M, Bell Douglas A, Eling Thomas E, Zeldin Darryl C

Abstract excerpt

OBJECTIVE: Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1. METHODS: Sequence variations in human PTGS1 were identified by resequencing 92 healthy individuals (24 African, 24 Asian, 24...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17301694
DOI: 10.1097/01.fpc.0000236340.87540.e3
PMCID: PMC2041861

Genes

PTGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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