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Article

Functional analysis of human thromboxane synthase polymorphic variants.

Pharmacogenetics and genomics - 1 Sept 2012

Chen Chung-Ying K, Poole Elizabeth M, Ulrich Cornelia M, Kulmacz Richard J, Wang Lee-Ho

Abstract excerpt

BACKGROUND: Thromboxane A synthase (TXAS) metabolizes the cyclooxygenase product prostaglandin (PG) H2 into thromboxane H2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Nonsynonymous polymorphisms in the TXAS gene have the potential to alter TXAS activity and affect TXA2 generation. OBJECTIVES: The aim of this study was to assess the functional effects of genetic variants in the...

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Identifiers

PMID: 22735388
DOI: 10.1097/FPC.0b013e3283562d82
PMCID: PMC4434599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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