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Article

Identification of genetic variants in the human thromboxane synthase gene (CYP5A1).

Mutation research - 1 Jan 2001

Chevalier D, Lo-Guidice J M, Sergent E, Allorge D, Debuysère H, Ferrari N, Libersa C, Lhermitte M, Broly F

Abstract excerpt

Thromboxane synthase (CYP5A1) catalyzes the conversion of prostaglandin H2 to thromboxane A2, a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction. It has been implicated in the patho-physiological process of a variety of diseases, such as atherosclerosis, myocardial infarction, stroke and asthma. On the basis of the hypothesis that variations of the CYP5A1 gene may play an...

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PMID: 11465543
DOI: 10.1016/s1383-5726(00)00004-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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