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Article

Directed evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomes.

Bioengineered - 1 Jan 2015

Kang Zhen, Zhang Junli, Jin Peng, Yang Sen

Abstract excerpt

Owing to our limited understanding of the relationship between sequence and function and the interaction between intracellular pathways and regulatory systems, the rational design of enzyme-coding genes and de novo assembly of a brand-new artificial genome for a desired functionality or phenotype are difficult to achieve. As an alternative approach, directed evolution has been widely used to engineer genomes and...

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Identifiers

PMID: 25621864
DOI: 10.1080/21655979.2015.1011029
PMCID: PMC4601291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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