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Article

Directed Evolution of Protein Catalysts.

Annual review of biochemistry - 20 Jun 2018

Zeymer Cathleen, Hilvert Donald

Abstract excerpt

Directed evolution is a powerful technique for generating tailor-made enzymes for a wide range of biocatalytic applications. Following the principles of natural evolution, iterative cycles of mutagenesis and screening or selection are applied to modify protein properties, enhance catalytic activities, or develop completely new protein catalysts for non-natural chemical transformations. This review briefly surveys...

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PMID: 29494241
DOI: 10.1146/annurev-biochem-062917-012034

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Source receipt: pubmed, retrieved 7 Sept 2026.

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