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Article

The diversity challenge in directed protein evolution.

Combinatorial chemistry & high throughput screening - 1 May 2006

Wong Tuck Seng, Zhurina Daria, Schwaneberg Ulrich

Abstract excerpt

Over the past decade, we have witnessed a bloom in the field of evolutive protein engineering which is fueled by advances in molecular biology techniques and high-throughput screening technology. Directed protein evolution is a powerful algorithm using iterative cycles of random mutagenesis and screening for tailoring protein properties to our needs in industrial applications and for elucidating proteins'...

Topics

Base Composition
Codon
Directed Molecular Evolution
Genetic Variation
Molecular Biology
Mutagenesis
Mutagenesis, Insertional
Polymerase Chain Reaction
Proteins
Random Allocation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16724918
DOI: 10.2174/138620706776843192

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