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Article

Recent advances in targeted mutagenesis to expedite the evolution of biological systems.

Journal of microbiology (Seoul, Korea) - 1 Mar 2025

Kim Seungjin, Lee Seungwon, Lim Hyun Gyu

Abstract excerpt

Evolution has been systematically exploited to engineer biological systems to obtain improved or novel functionalities by selecting beneficial mutations. Recent innovations in continuous targeted mutagenesis within living cells have emerged to generate large sequence diversities without requiring multiple steps. This review comprehensively introduces recent advancements in this field, categorizing them into three...

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Topics

Directed Molecular Evolution
Mutagenesis
Mutation
DNA-Directed DNA Polymerase
Metabolic Engineering
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Homologous Recombination

Evolution, Molecular

Source

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Identifiers

PMID: 40195835
DOI: 10.71150/jm.2501008
PMCID: PMC13577105

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