Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequences of 2 octogenarians with sustained cognitive abilities.

Neurobiology of aging - 1 Mar 2015

Nickles Dorothee, Madireddy Lohith, Patel Nihar, Isobe Noriko, Miller Bruce L, Baranzini Sergio E, Kramer Joel H, Oksenberg Jorge R

Abstract excerpt

Although numerous genetic variants affecting aging and mortality have been identified, for example, apolipoprotein E ε4, the genetic component influencing cognitive aging has not been fully defined yet. A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes. Here, we describe the whole genome sequences of 2 female octogenarians. We provide the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apolipoprotein E4
Share to Cognition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Overlapping

Share to Genome, Human

Share to Genomics

Share to Longevity

Share to Precision Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 25618617
DOI: 10.1016/j.neurobiolaging.2014.11.003
PMCID: PMC4346472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequences of 2 octogenarians with sustained cognitive abilities.PMID 25618617Read ↗

Whole-Genome Sequencing of a Healthy Aging Cohort.Semantic proximity Read ↗

Rare and common variants in the Apolipoprotein E gene in healthy oldest old.Semantic proximity Read ↗

Genetic variation in healthy oldest-old.Semantic proximity Read ↗

Centenarians and Oldest Olds in Liguria – COOL: a multidisciplinary study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and cohort profileSemantic proximity Read ↗

Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum.Semantic proximity Read ↗

Genetic variation and human aging: progress and prospects.Semantic proximity Read ↗

Rare genetic coding variants associated with human longevity and protection against age-related diseases.Semantic proximity Read ↗

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.Semantic proximity Read ↗

Genetic signatures of exceptional longevity in humans.Semantic proximity Read ↗

The genetics of cognitive ability and cognitive ageing in healthy older people.Semantic proximity Read ↗

The genetics of exceptional longevity: Insights from centenarians.Semantic proximity Read ↗

Genetic Investigation of an Iranian Supercentenarian by Whole Exome Sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.