Article
Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2015
Borst Oliver, Schaub Malte, Walker Britta, Schmid Evi, Münzer Patrick, Voelkl Jakob, Alesutan Ioana, Rodríguez José M, Vogel Sebastian, Schoenberger Tanja, Metzger Katja, Rath Dominik, Umbach Anja, Kuhl Dietmar, Müller Iris I, Seizer Peter, Geisler Tobias, Gawaz Meinrad, Lang Florian
Abstract excerpt
OBJECTIVE: Atherosclerosis, an inflammatory disease of arterial vessel walls, requires migration and matrix metalloproteinase (MMP)-9-dependent invasion of monocytes/macrophages into the vascular wall. MMP-9 expression is stimulated by transcription factor nuclear factor-κB, which is regulated by inhibitor κB (IκB) and thus IκB kinase. Regulators of nuclear factor-κB include serum- and glucocorticoid-inducible...
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