Article
Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB Pathways.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016
Sun Jian-Yong, Li Chao, Shen Zhu-Xia, Zhang Wu-Chang, Ai Tang-Jun, Du Lin-Juan, Zhang Yu-Yao, Yao Gao-Feng, Liu Yan, Sun Shuyang, Naray-Fejes-Toth Aniko, Fejes-Toth Geza, Peng Yong, Chen Mao, Liu Xiaojing, Tao Jun, Zhou Bin, Yu Ying, Guo Feifan, Du Jie, Duan Sheng-Zhong
Abstract excerpt
OBJECTIVE: Restenosis after percutaneous coronary intervention remains to be a serious medical problem. Although mineralocorticoid receptor (MR) has been implicated as a potential target for treating restenosis, the cellular and molecular mechanisms are largely unknown. This study aims to explore the functions of macrophage MR in neointimal hyperplasia and to delineate the molecular mechanisms. APPROACH AND...
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