Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction.

PloS one - 1 Jan 2013

Zarrinpashneh Elham, Poggioli Tommaso, Sarathchandra Padmini, Lexow Jonas, Monassier Laurent, Terracciano Cesare, Lang Florian, Damilano Federico, Zhou Jessica Q, Rosenzweig Anthony, Rosenthal Nadia, Santini Maria Paola

Abstract excerpt

Serum and glucocorticoid inducible kinase 1 (SGK1) plays a pivotal role in early angiogenesis during embryonic development. In this study, we sought to define the SGK1 downstream signalling pathways in the adult heart and to elucidate their role in cardiac neo-angiogenesis and wound healing after myocardial ischemia. To this end, we employed a viable SGK1 knockout mouse model generated in a 129/SvJ background....

Topics

Join the communities discussing this publication.

Cell Size
Endothelial Cells
Fibrosis
Immediate-Early Proteins
Myocardial Infarction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardial Ischemia

Myocytes, Cardiac

Neovascularization, Pathologic

Source

Open in PubMed Open full text

Identifiers

PMID: 24265802
DOI: 10.1371/journal.pone.0080268
PMCID: PMC3827188

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction.PMID 24265802Read ↗

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host DiseaseSemantic proximity Read ↗

Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction.Semantic proximity Read ↗

NLGN3 contributes to angiogenesis in myocardial infarction via activation of the Gαi1/3-Akt PathwaySemantic proximity Read ↗

SGK1 contributes to endothelial cell ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathwaySemantic proximity Read ↗

Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth.Semantic proximity Read ↗

SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Thoracic Aortic Dissection Progression.Semantic proximity Read ↗

SGK1 in Human Cancer: Emerging Roles and MechanismsSemantic proximity Read ↗

Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.Semantic proximity Read ↗

WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.Semantic proximity Read ↗

A novel serum glucocorticoid regulated kinase 1 inhibitor improves cardiac structure and function in heart failureSemantic proximity Read ↗

SMOC1 Regulates Endothelial-to-Mesenchymal Transition During Cardiac Repair After Myocardial InfarctionSemantic proximity Read ↗

Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.