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Article

Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.

Angiogenesis - 1 May 2018

Araki Mutsumi, Hisamitsu Takashi, Kinugasa-Katayama Yumi, Tanaka Toru, Harada Yukihiro, Nakao Shu, Hanada Sanshiro, Ishii Shuhei, Fujita Masahide, Kawamura Teruhisa, Saito Yoshihiko, Nishiyama Koichi, Watanabe Yusuke, Nakagawa Osamu

Abstract excerpt

Bone morphogenetic protein 9 (BMP9)/BMP10-ALK1 receptor signaling is essential for endothelial differentiation and vascular morphogenesis. Mutations in ALK1/ACVRL1 and other signal-related genes are implicated in human vascular diseases, and the Alk1/Acvrl1 deletion in mice causes severe impairment of vascular formation and embryonic lethality. In the microarray screen to search for novel downstream genes of ALK1...

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Share to Activin Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Human Umbilical Vein Endothelial Cells

Share to Immediate-Early Proteins

Share to Neovascularization, Physiologic

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Source

Identifiers

PMID: 29478089
DOI: 10.1007/s10456-018-9605-x

Genes

SGK1
BMP10
ACVRL1
SMAD1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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