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Article

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Wolfsgruber Wiebke, Feil Susanne, Brummer Sabine, Kuppinger Oliver, Hofmann Franz, Feil Robert

Abstract excerpt

Nitric oxide (NO) exerts both antiatherogenic and proatherogenic effects, but the cellular and molecular mechanisms that contribute to modulation of atherosclerosis by NO are not understood completely. The cGMP-dependent protein kinase I (cGKI) is a potential mediator of NO signaling in vascular smooth muscle cells (SMCs). Postnatal ablation of cGKI selectively in the SMCs of mice reduced atherosclerotic lesion...

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Identifiers

PMID: 14597716
DOI: 10.1073/pnas.1936024100
PMCID: PMC263846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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