Article
Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice.
Atherosclerosis - 1 Jan 2020
Tilstam Pathricia V, Soppert Josefin, Hemmers Christian, Harlacher Eva, Döring Yvonne, van der Vorst Emiel P C, Schulte Corinna, Alampour-Rajabi Setareh, Theelen Wendy, Asare Yaw, de Winther Menno P J, Lawrence Toby, Bernhagen Jürgen, Schober Andreas, Zernecke Alma, Jankowski Joachim, Weber Christian, Noels Heidi
Abstract excerpt
BACKGROUND AND AIMS: IKKα is an important regulator of gene expression. As IKKα kinase inactivity in bone marrow-derived cells does not affect atherosclerosis, we here investigate the impact of a whole body-IKKα kinase inactivity on atherosclerosis. METHODS: Apolipoprotein E (Apoe)-deficient mice homozygous for an activation-resistant Ikkα-mutant (IkkαAA/AAApoe-/-) and Ikkα+/+Apoe-/- controls received a...
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