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Article

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

17 Jan 2015

Abstract excerpt

In principle, a decline in base excision repair (BER) efficiency with age should lead to genomic instability and ultimately contribute to the onset of the aging phenotype. Although multiple studies have indicated a negative link between aging and BER, the change of BER efficiency with age in humans has not been systematically analyzed. Here, with foreskin fibroblasts isolated from 19 donors between 20 and 64 y of...

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Identifiers

PMID: 25607651
DOI: 10.4161/15384101.2014.980641

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