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The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells

21 Jul 2020

Abstract excerpt

Cellular reprogramming is an emerging strategy for delaying the aging processes. However, a number of challenges, including the impaired genome integrity and decreased pluripotency of induced pluripotent stem cells (iPSCs) derived from old donors, may hinder their potential clinical applications. The longevity gene, Sirtuin 6 (SIRT6), functions in multiple biological processes such as the maintenance of genome...

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PMID: 33089974
DOI: 10.1111/acel.13185

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