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Article

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

3 Jun 2014

Abstract excerpt

Mesenchymal stem cells (MSCs) senescence is an age-related process that impairs the capacity for tissue repair and compromises the clinical use of autologous MSCs for tissue regeneration. Here, we describe the effects of SIRT1, a NAD(+)-dependent deacetylase, on age-related MSCs senescence. Knockdown of SIRT1 in young MSCs induced cellular senescence and inhibited cell proliferation whereas overexpression of...

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PMID: 24917814
DOI: 10.3389/fnagi.2014.00103

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