Article
Crosstalk between age accumulated DNA-damage and the SIRT1-AKT-GSK3ß axis in urine derived renal progenitor cells
2022-05-07
Abstract excerpt
The aging process is manifested by a multitude of interlinked biological processes. These processes contribute to genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. Together these are recognized as of the main risk factors of the world’s mo...
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Identifiers and source
- Literature Corpus work
- c39b6b71-f84d-5e6e-ba9d-5022ef6b0b43
- DOI
- 10.1101/2022.05.07.491023