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Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

9 Dec 2023

Abstract excerpt

While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. The purpose of this study was to determine whether a decline in DNA repair efficiency is one...

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PMID: 38078876
DOI: 10.18632/aging.205394

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