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Article

Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2015

Kamat Nikhil V, Thabet Salim R, Xiao Liang, Saleh Mohamed A, Kirabo Annet, Madhur Meena S, Delpire Eric, Harrison David G, McDonough Alicia A

Abstract excerpt

Ample genetic and physiological evidence establishes that renal salt handling is a critical regulator of blood pressure. Studies also establish a role for the immune system, T-cell infiltration, and immune cytokines in hypertension. This study aimed to connect immune cytokines, specifically interferon-γ (IFN-γ) and interleukin-17A (IL-17A), to sodium transporter regulation in the kidney during angiotensin-II...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25601932
DOI: 10.1161/HYPERTENSIONAHA.114.04975
PMCID: PMC4326622

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