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Article

Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in Npr1 haplotype male mice.

American journal of physiology. Renal physiology - 1 Sept 2017

Kumar Prerna, Gogulamudi Venkateswara R, Periasamy Ramu, Raghavaraju Giri, Subramanian Umadevi, Pandey Kailash N

Abstract excerpt

Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) plays a critical role in the regulation of blood pressure and fluid volume homeostasis. Mice lacking functional Npr1 (coding for GC-A/NPRA) exhibit hypertension and congestive heart failure. However, the underlying mechanisms remain largely less clear. The objective of the present study was to determine the physiological efficacy and impact of...

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Source

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Identifiers

PMID: 28566502
DOI: 10.1152/ajprenal.00166.2017
PMCID: PMC5625105

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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