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Article

The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells.

Molecular pharmaceutics - 2 Mar 2015

Knops Noël, van den Heuvel Lambertus P, Masereeuw Rosalinde, Bongaers Inge, de Loor Henriëtte, Levtchenko Elena, Kuypers Dirk

Abstract excerpt

BACKGROUND: Calcineurin inhibitors (CNIs) are the primary immunosuppressive drugs used in solid organ transplantation but are associated with the development of histological lesions leading to kidney failure. CNIs are metabolized by CYP3A and excreted by not only P-glycoprotein (P-gp) (ABCB1) in the gut and liver, but also by proximal tubule cells (PTCs) in the kidney. Multiple studies have demonstrated the...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25590378
DOI: 10.1021/mp500590s

Genes

ABCB1
AQP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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