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Article

The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation.

Expert opinion on drug metabolism & toxicology - 1 Jun 2011

Picard Nicolas, Marquet Pierre

Abstract excerpt

INTRODUCTION: Immunosuppressive drugs have a narrow therapeutic range and large inter-individual response variability. This has prompted pharmacogenetic studies, mostly with regard to their dose-concentration relationships, but also about proteins involved in their pharmacodynamics. Some polymorphisms of genes involved in their disposition pathways were shown to affect their dose-concentration relationships. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21434840
DOI: 10.1517/17425255.2011.570260
PMCID: PMC3326718

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