Article
Frequencies and roles of CYP3A5, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation.
Pharmacological reports : PR - 1 Jan 2000
Turolo Stefano, Tirelli Amedea S, Ferraresso Mariano, Ghio Luciana, Belingheri Mirco, Groppali Elena, Torresani Erminio, Edefonti Alberto
Abstract excerpt
The main genes involved in the pharmacokinetics of immunosuppressive drugs are those encoding cytochrome P450 (CYP) family enzymes and multidrug resistance 1 (ABCB1). In this study, 87 Italian teenagers with transplanted kidneys (mean age 11.6 ± 4.8 years) receiving calcineurin inhibitors (CNIs)...
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