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Article

Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 28 Feb 2023

Knops Noël, Ramazani Yasaman, De Loor Henriëtte, Goldschmeding Roel, Nguyen Tri Q, van den Heuvel Lambert P, Levtchenko Elena, Kuypers Dirk J

Abstract excerpt

BACKGROUND: Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but their importance is unclear because of the multifactorial background of renal fibrosis. This study explores the pro-fibrotic response of tacrolimus exposure in relation to the differential capacity for tacrolimus metabolism in proximal tubule...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35945682
DOI: 10.1093/ndt/gfac237
PMCID: PMC9976759

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Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes.PMID 35945682Read ↗

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