Article
Clinical implementation of pharmacogenetics in kidney transplantation: calcineurin inhibitors in the starting blocks.
British journal of clinical pharmacology - 1 Apr 2014
Elens Laure, Bouamar Rachida, Shuker Nauras, Hesselink Dennis A, van Gelder Teun, van Schaik Ron H N
Abstract excerpt
Pharmacogenetics has generated many expectations for its potential to individualize therapy proactively and improve medical care. However, despite the huge amount of reported genetic associations with either pharmacokinetics or pharmacodynamics of drugs, the translation into patient care is still slow. In fact, strong evidence for a substantial clinical benefit of pharmacogenetic testing is still limited, with a...
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