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Pharmacogenetics and drug-induced nephrotoxicity in renal transplant recipients

29 Mar 2015

Abstract excerpt

INTRODUCTION: The advent of calcineurin inhibitors (CNIs), as the leading immunosuppressive agents, not only has revolutionized the transplant medicine but also made it a better therapeutic intervention that guarantees the graft outcome and improves the survival rate of patients. However, genetic polymorphism(s) in the CNIs metabolic substrates genes (CYP3A4, CYP3A5) and their transporter such as P-glycoprotein...

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PMID: 25901296
DOI: 10.15171/bi.2015.12

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