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CYP3A5 genotype-phenotype analysis in the human kidney reveals a strong site-specific expression of CYP3A5 in the proximal tubule in carriers of the CYP3A5*1 allele.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2012

Bolbrinker Juliane, Seeberg Stefanie, Schostak Martin, Kempkensteffen Carsten, Baelde Hans, de Heer Emile, Kreutz Reinhold

Abstract excerpt

Interindividual variability in the drug-metabolizing activity of the CYP3A5 enzyme is mainly due to a single nucleotide polymorphism in CYP3A5, leading to low expression in homozygous CYP3A5*3/*3 individuals compared with CYP3A5*1 allele carriers. In the human kidney, expression of CYP3A5 has been implicated in blood pressure regulation and calcineurin inhibitor-associated nephrotoxicity. The effect of the...

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Identifiers

PMID: 22214815
DOI: 10.1124/dmd.111.042648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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