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Article

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

13 Jan 2015

Abstract excerpt

Alternative non-homologous end joining (alt-NHEJ) was originally identified as a backup repair mechanism in the absence of classical NHEJ (c-NHEJ) factors but recent studies have demonstrated that alt-NHEJ is active even when c-NHEJ as well as homologous recombination is available. The functions of 53BP1 in NHEJ processes are not well understood. Here, we report that 53BP1 promotes DNA double-strand break (DSB)...

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PMID: 25586219
DOI: 10.1093/nar/gku1406

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