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Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ

16 Oct 2020

Abstract excerpt

The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand break (DSB) repair in cells deficient for NHEJ or homologous recombination, suggesting that it operates at all stages of the cell cycle. Here, we use an approach in which DNA breaks can be induced in G1 cells and their repair tracked, enabling us to show that joining of DSBs is not functional in G1-arrested XRCC4-deficient cells....

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PMID: 33067475
DOI: 10.1038/s41467-020-19060-w

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