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Article

A systematic heritability analysis of the human whole blood transcriptome.

Human genetics - 1 Mar 2015

Huan Tianxiao, Liu Chunyu, Joehanes Roby, Zhang Xiaoling, Chen Brian H, Johnson Andrew D, Yao Chen, Courchesne Paul, O'Donnell Christopher J, Munson Peter J, Levy Daniel

Abstract excerpt

Genome-wide expression quantitative trait locus (eQTL) mapping may reveal common genetic variants regulating gene expression. In addition to mapping eQTLs, we systematically evaluated the heritability of the whole blood transcriptome in 5,626 participants from the Framingham Heart Study. Of all gene expression measurements, about 40 % exhibit evidence of being heritable [hgeneExp(2) > 0, (p < 0.05)], the average...

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Identifiers

PMID: 25585846
DOI: 10.1007/s00439-014-1524-3
PMCID: PMC4339826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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