Predicting tissue-specific gene expression from whole blood transcriptome

Abstract excerpt

Complex diseases are systemic, largely mediated via transcriptional dysregulation in multiple tissues. Thus, knowledge of tissue-specific transcriptome in an individual can provide important information about an individual’s health. Unfortunately, with a few exceptions such as blood, skin, and muscle, an individual’s tissue-specific transcriptome is not accessible through non-invasive means. However, due to shared...

Topics

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• Bayes Theorem
• Gene Expression Regulation
• Models, Genetic
• Multifactorial Inheritance
• Organ Specificity
• Polymorphism, Single Nucleotide
• Quantitative Trait, Heritable
• Sample Size

Identifiers and source

Literature Corpus work

415238ba-ef1e-5530-a4e8-9669d6502e44

DOI

10.1101/2020.05.10.086942