Article

Survey of the Heritability and Sparse Architecture of Gene Expression Traits Across Human Tissues

2016-03-15

Abstract excerpt

Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body. We find that local h 2 can be relatively well characterized with 59% of expressed genes showing significant h 2 (FDR...

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Literature Corpus work: 4fc834d1-ef59-55b6-95f5-c0e7c65cd0ba
DOI: 10.1101/043653

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