Article
Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.
PloS one - 1 Jan 2018
Manichaikul Ani, Wang Xin-Qun, Li Li, Erdmann Jeanette, Lettre Guillaume, Bis Joshua C, Waterworth Dawn, Cushman Mary, Jenny Nancy S, Post Wendy S, Palmas Walter, Tsai Michael Y, Wallentin Lars, White Harvey, Schunkert Heribert, O'Donnell Christopher J, Herrington David M, Rich Stephen S, O'Donoghue Michelle L, Rodriguez Annabelle
Abstract excerpt
BACKGROUND: We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA2 mass and activity, we hypothesized that inflammatory pathways might mediate the association of rs10846744 with atherosclerosis. METHODS: We first examined association of rs10846744 in CVD in multiple...