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Article

Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart Disease

4 Sept 2015

Abstract excerpt

Over the last 10 to 15 years, animal and human observational studies have identified elevated levels of both proinflammatory secretory phospholipase A2-IIA and lipoprotein-associated phospholipase A2 as potential risk factors for coronary heart disease. However, Mendelian randomization, a genetic tool to test causality of a biomarker, and phase III randomized controlled trials of inhibitors of theses enzymes...

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PMID: 26338298
DOI: 10.1161/atvbaha.115.305234

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