Article
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.
Human molecular genetics - 15 Jun 2007
Wootton Peter T E, Arora Nupur L, Drenos Fotios, Thompson Simon R, Cooper Jackie A, Stephens Jeffrey W, Hurel Steven J, Hurt-Camejo Eva, Wiklund Olov, Humphries Steve E, Talmud Philippa J
Abstract excerpt
Animal and human studies suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis. Elevated plasma sPLA2-IIA predicts coronary heart disease (CHD) risk, but no mass assay for sPLA2-V is available. We...
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